Review



bcl2  (Proteintech)


Bioz Verified Symbol Proteintech is a verified supplier  
  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
    • 96
      Buy from Supplier

    Structured Review

    Proteintech bcl2
    NRP2 mediates the FAK signaling pathway to regulate the malignant progression of GBM cells. (A): NRP2 expression levels in patients from the GSE4290 and GSE68848 data sets. (B): The knockdown effect of sh-NRP2 in U251 and T98G cells was detected by qRT-PCR. (C): WB was used to detect the expressions of pY297-FAK and FAK. (D): The CCK-8 method was used to detect the cell viability of GBM cells in different treatment groups (sh-NC, sh-NRP2, sh-NRP2 + adhesamine). Adhesamine is a FAK activator. (E): The colony formation experiment was used to detect the number of colony formations of GBM cells in different treatment groups; (F): The scratch healing experiment was used to detect the migration ability of GBM cells in different treatment groups; (G): The Transwell experiment was used to detect the invasion ability of GBM cells in different treatment groups; (H): The Annexin V/PI double staining method was used to detect the apoptosis level of cells in different treatment groups. (I): Western blot was used to detect the protein expression of pro-apoptotic indicators clever-caspase3, clever-PARP, BAX and pro-apoptotic indicator <t>BCL2</t> in different treatment groups. * indicates P < 0.05, **** indicates P < 0.0001.
    Bcl2, supplied by Proteintech, used in various techniques. Bioz Stars score: 96/100, based on 4675 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/bcl2+antibody/BCL2+Antibody/pmc13018971-13-0-2
    Average 96 stars, based on 4675 article reviews
    bcl2 - by Bioz Stars, 2026-09
    96/100 stars

    Images

    1) Product Images from "The brain imaging feature-related gene NRP2 drives the malignant progression of glioblastoma through the FAK pathway: a Mendelian randomization study"

    Article Title: The brain imaging feature-related gene NRP2 drives the malignant progression of glioblastoma through the FAK pathway: a Mendelian randomization study

    Journal: Translational Oncology

    doi: 10.1016/j.tranon.2026.102732

    NRP2 mediates the FAK signaling pathway to regulate the malignant progression of GBM cells. (A): NRP2 expression levels in patients from the GSE4290 and GSE68848 data sets. (B): The knockdown effect of sh-NRP2 in U251 and T98G cells was detected by qRT-PCR. (C): WB was used to detect the expressions of pY297-FAK and FAK. (D): The CCK-8 method was used to detect the cell viability of GBM cells in different treatment groups (sh-NC, sh-NRP2, sh-NRP2 + adhesamine). Adhesamine is a FAK activator. (E): The colony formation experiment was used to detect the number of colony formations of GBM cells in different treatment groups; (F): The scratch healing experiment was used to detect the migration ability of GBM cells in different treatment groups; (G): The Transwell experiment was used to detect the invasion ability of GBM cells in different treatment groups; (H): The Annexin V/PI double staining method was used to detect the apoptosis level of cells in different treatment groups. (I): Western blot was used to detect the protein expression of pro-apoptotic indicators clever-caspase3, clever-PARP, BAX and pro-apoptotic indicator BCL2 in different treatment groups. * indicates P < 0.05, **** indicates P < 0.0001.
    Figure Legend Snippet: NRP2 mediates the FAK signaling pathway to regulate the malignant progression of GBM cells. (A): NRP2 expression levels in patients from the GSE4290 and GSE68848 data sets. (B): The knockdown effect of sh-NRP2 in U251 and T98G cells was detected by qRT-PCR. (C): WB was used to detect the expressions of pY297-FAK and FAK. (D): The CCK-8 method was used to detect the cell viability of GBM cells in different treatment groups (sh-NC, sh-NRP2, sh-NRP2 + adhesamine). Adhesamine is a FAK activator. (E): The colony formation experiment was used to detect the number of colony formations of GBM cells in different treatment groups; (F): The scratch healing experiment was used to detect the migration ability of GBM cells in different treatment groups; (G): The Transwell experiment was used to detect the invasion ability of GBM cells in different treatment groups; (H): The Annexin V/PI double staining method was used to detect the apoptosis level of cells in different treatment groups. (I): Western blot was used to detect the protein expression of pro-apoptotic indicators clever-caspase3, clever-PARP, BAX and pro-apoptotic indicator BCL2 in different treatment groups. * indicates P < 0.05, **** indicates P < 0.0001.

    Techniques Used: Expressing, Knockdown, Quantitative RT-PCR, CCK-8 Assay, Migration, Double Staining, Western Blot

    NRP2 promotes the malignant progression of GBM by activating FAK. U251 and T98G cell groups: sh-NC, sh-NRP2, sh-NRP2 + oe-FAK. (A): qRT-PCR was used to detect the mRNA level of FAK; (B): WB was used to detect the protein expression of pY397-FAK and FAK; (C): CCK-8 was used to detect cell viability; (D): Scratch test was used to detect the migration ability of cells; (E): Transwell test was used to detect the invasion ability of cells; (F): WB was used to detect the protein expression of apoptotic proteins clever-caspase3, clever-PARP, BAX and anti-apoptotic protein BCL2. * indicates P < 0.05.
    Figure Legend Snippet: NRP2 promotes the malignant progression of GBM by activating FAK. U251 and T98G cell groups: sh-NC, sh-NRP2, sh-NRP2 + oe-FAK. (A): qRT-PCR was used to detect the mRNA level of FAK; (B): WB was used to detect the protein expression of pY397-FAK and FAK; (C): CCK-8 was used to detect cell viability; (D): Scratch test was used to detect the migration ability of cells; (E): Transwell test was used to detect the invasion ability of cells; (F): WB was used to detect the protein expression of apoptotic proteins clever-caspase3, clever-PARP, BAX and anti-apoptotic protein BCL2. * indicates P < 0.05.

    Techniques Used: Quantitative RT-PCR, Expressing, CCK-8 Assay, Migration

    The nude mouse experiment demonstrates that NRP2 mediates the Focal-adhesion pathway to regulate the formation of GBM tumors. (A): Nude mice were subcutaneously injected with sh-NRP2 and sh-NC stably transfected T98G cells. Comparison of tumor size in sh-NRP2 nude mice treated with FAK activator adhesamine. (B): Tumor weights of different treatment groups of nude mice. (C): Tumor volumes of different treatment groups of nude mice. (D): IHC detection of the expression of Ki67, BCL2 and BAX in tumor tissues; (E): WB detection of the expression of pY297-FAK and FAK in tumor tissues.
    Figure Legend Snippet: The nude mouse experiment demonstrates that NRP2 mediates the Focal-adhesion pathway to regulate the formation of GBM tumors. (A): Nude mice were subcutaneously injected with sh-NRP2 and sh-NC stably transfected T98G cells. Comparison of tumor size in sh-NRP2 nude mice treated with FAK activator adhesamine. (B): Tumor weights of different treatment groups of nude mice. (C): Tumor volumes of different treatment groups of nude mice. (D): IHC detection of the expression of Ki67, BCL2 and BAX in tumor tissues; (E): WB detection of the expression of pY297-FAK and FAK in tumor tissues.

    Techniques Used: Injection, Stable Transfection, Transfection, Comparison, Expressing

    Related Articles

    Membrane:

    Article Title: Lobaric Acid Exhibits Anticancer Potential by Modulating the Wnt/β-Catenin Signaling Pathway in MCF-7 Cells.
    Article Snippet: Cells were incubated with IC50 concentration of LA for 48 h and proteins (10 μg) from cells lysed with radioimmunoprecipitation assay buffer (RIPA, Cell Signaling Technology) were separated by 12% SDS- PAGE. .. Subsequently, membrane incubation was performed overnight at 4°C using P53 antibody (Proteintech, 10442- 1- AP, 1:1000), BCL2 antibody (Proteintech 12789- 1- AP 1:500), WNT2 antibody (Proteintech, 66656- I- Ig, 1:1000), AXIN antibody (Proteintech, 68093- 1- Ig, 1:1000), β- Catenin antibody (Santa Cruz Biotechnology, sc- 7963, 1:1000), GSK3- β antibody (Santa Cruz, sc- 377213, 1:1000), and β- Actin antibody (Santa Cruz Biotechnology, sc- 47778, 1:1000). .. Protein samples were visualized after application of horseradish- linked secondary antibodies (Santa Cruz Biotechnology) at 1:10 000 dilution and exposure to a chemiluminescence detection system (ECL Clarity/ ECL Clarity Max Substrate, Biorad).

    Article Title: Lobaric Acid Exhibits Anticancer Potential by Modulating the Wnt/β‐Catenin Signaling Pathway in MCF‐7 Cells
    Article Snippet: Cells were incubated with IC 50 concentration of LA for 48 h and proteins (10 μg) from cells lysed with radioimmunoprecipitation assay buffer (RIPA, Cell Signaling Technology) were separated by 12% SDS‐PAGE. .. Subsequently, membrane incubation was performed overnight at 4°C using P53 antibody (Proteintech, 10442‐1‐AP, 1:1000), BCL2 antibody (Proteintech 12789‐1‐AP 1:500), WNT2 antibody (Proteintech, 66656‐I‐Ig, 1:1000), AXIN antibody (Proteintech, 68093‐1‐Ig, 1:1000), β‐Catenin antibody (Santa Cruz Biotechnology, sc‐7963, 1:1000), GSK3‐ β antibody (Santa Cruz, sc‐377213, 1:1000), and β‐Actin antibody (Santa Cruz Biotechnology, sc‐47778, 1:1000). .. Protein samples were visualized after application of horseradish‐linked secondary antibodies (Santa Cruz Biotechnology) at 1:10 000 dilution and exposure to a chemiluminescence detection system (ECL Clarity/ECL Clarity Max Substrate, Biorad).

    Incubation:

    Article Title: Lobaric Acid Exhibits Anticancer Potential by Modulating the Wnt/β-Catenin Signaling Pathway in MCF-7 Cells.
    Article Snippet: Cells were incubated with IC50 concentration of LA for 48 h and proteins (10 μg) from cells lysed with radioimmunoprecipitation assay buffer (RIPA, Cell Signaling Technology) were separated by 12% SDS- PAGE. .. Subsequently, membrane incubation was performed overnight at 4°C using P53 antibody (Proteintech, 10442- 1- AP, 1:1000), BCL2 antibody (Proteintech 12789- 1- AP 1:500), WNT2 antibody (Proteintech, 66656- I- Ig, 1:1000), AXIN antibody (Proteintech, 68093- 1- Ig, 1:1000), β- Catenin antibody (Santa Cruz Biotechnology, sc- 7963, 1:1000), GSK3- β antibody (Santa Cruz, sc- 377213, 1:1000), and β- Actin antibody (Santa Cruz Biotechnology, sc- 47778, 1:1000). .. Protein samples were visualized after application of horseradish- linked secondary antibodies (Santa Cruz Biotechnology) at 1:10 000 dilution and exposure to a chemiluminescence detection system (ECL Clarity/ ECL Clarity Max Substrate, Biorad).

    Article Title: Lobaric Acid Exhibits Anticancer Potential by Modulating the Wnt/β‐Catenin Signaling Pathway in MCF‐7 Cells
    Article Snippet: Cells were incubated with IC 50 concentration of LA for 48 h and proteins (10 μg) from cells lysed with radioimmunoprecipitation assay buffer (RIPA, Cell Signaling Technology) were separated by 12% SDS‐PAGE. .. Subsequently, membrane incubation was performed overnight at 4°C using P53 antibody (Proteintech, 10442‐1‐AP, 1:1000), BCL2 antibody (Proteintech 12789‐1‐AP 1:500), WNT2 antibody (Proteintech, 66656‐I‐Ig, 1:1000), AXIN antibody (Proteintech, 68093‐1‐Ig, 1:1000), β‐Catenin antibody (Santa Cruz Biotechnology, sc‐7963, 1:1000), GSK3‐ β antibody (Santa Cruz, sc‐377213, 1:1000), and β‐Actin antibody (Santa Cruz Biotechnology, sc‐47778, 1:1000). .. Protein samples were visualized after application of horseradish‐linked secondary antibodies (Santa Cruz Biotechnology) at 1:10 000 dilution and exposure to a chemiluminescence detection system (ECL Clarity/ECL Clarity Max Substrate, Biorad).

    Recombinant:

    Article Title: Capicua mediates interleukin-2 withdrawal–induced death of activated CD8+ T cells
    Article Snippet: .. Materials and methods 336 4.1 Reagents and antibodies 337 Reagents and antibodies used in this study were obtained from the indicated sources: 338 Recombinant human IL-2 (SL Pharm, S19991010); Annexin V-FITC/PI Apoptosis Kit 339 (Elabscience, E-CK-A211); Actinomycin D (MCE, HY-17559 ); TrueCut Cas9 340 Protein (Invitrogen, A36498); Nuclear and Cytoplasmic Extraction Reagents 341 (Thermo, 78835); Zombie VioletTM Fixable Viability Kit (BioLegend, 423113); 342 Pacific Blue anti-mouse CD3 Antibody (BioLegend, 100214); FITC anti-mouse CD8a 343 Antibody (BioLegend, 100706); APC anti-mouse CD8a Antibody (BD Pharmingen, 344 553035); PE/Cyanine7 anti-mouse CD3 Antibody (BioLegend, 100220); APC anti-345 mouse IFN-γ Antibody (Invivogen, 17-7311-82); PE-Labeled Mouse H-346 2Kb&B2M&OVA (SIINFEKL) Tetramer Protein (Acrobiosystems, H2A-MP2H7); 347 Capicua Antibody (Novusbio, NB110-59906); anti-FLAG Antibody (Sigma-Aldrich, 348 F3165); β-actin (Sigma-Aldrich, A2228); Bim Antibody (Cell Signaling Technology, 349 2933T); Bcl-2 Antibody (Cell Signaling Technology, 3498T); Bax Antibody (Cell 350 Signaling Technology, 2772T); Bcl2 antibody (Proteintech, 68103-1-Ig); BAX 351 antibody (Proteintech, 60267-1-Ig); KEAP1 antibody (Proteintech, 10503-2-AP); 352 Anti-mouse Ig HRP (Rockland Immunochemicals, 18-8817-33); Anti-rabbit IgG HRP 353 (Rockland Immunochemicals, 18-8816-33); HRP-conjugated Mouse anti-Rabbit IgG 354 Light Chain (ABclonal, AS061); Prestained Protein Ladder 10-180 kDa (Thermo, 355 26616); Prestained Protein Ladder 25-400 kDa (Sevenbio, SW179). .. 356 4.2 Cells 357 CTLL-2 cells were purchased from the Cell Resource Center, Peking Union Medical 358 College (IBMS, CAMS/PUMC) and cultured in RPMI-1640 (Gibco) supplemented 359 with 10% fetal bovine serum (FBS) and 1× penicillin–streptomycin (Invitrogen), 10 360 mM HEPES, 1 mM Sodium pyruvate (Gibco), 2mM GlutaMAX (Gibco), and 100 361 U/ml IL-2.

    Extraction:

    Article Title: Capicua mediates interleukin-2 withdrawal–induced death of activated CD8+ T cells
    Article Snippet: .. Materials and methods 336 4.1 Reagents and antibodies 337 Reagents and antibodies used in this study were obtained from the indicated sources: 338 Recombinant human IL-2 (SL Pharm, S19991010); Annexin V-FITC/PI Apoptosis Kit 339 (Elabscience, E-CK-A211); Actinomycin D (MCE, HY-17559 ); TrueCut Cas9 340 Protein (Invitrogen, A36498); Nuclear and Cytoplasmic Extraction Reagents 341 (Thermo, 78835); Zombie VioletTM Fixable Viability Kit (BioLegend, 423113); 342 Pacific Blue anti-mouse CD3 Antibody (BioLegend, 100214); FITC anti-mouse CD8a 343 Antibody (BioLegend, 100706); APC anti-mouse CD8a Antibody (BD Pharmingen, 344 553035); PE/Cyanine7 anti-mouse CD3 Antibody (BioLegend, 100220); APC anti-345 mouse IFN-γ Antibody (Invivogen, 17-7311-82); PE-Labeled Mouse H-346 2Kb&B2M&OVA (SIINFEKL) Tetramer Protein (Acrobiosystems, H2A-MP2H7); 347 Capicua Antibody (Novusbio, NB110-59906); anti-FLAG Antibody (Sigma-Aldrich, 348 F3165); β-actin (Sigma-Aldrich, A2228); Bim Antibody (Cell Signaling Technology, 349 2933T); Bcl-2 Antibody (Cell Signaling Technology, 3498T); Bax Antibody (Cell 350 Signaling Technology, 2772T); Bcl2 antibody (Proteintech, 68103-1-Ig); BAX 351 antibody (Proteintech, 60267-1-Ig); KEAP1 antibody (Proteintech, 10503-2-AP); 352 Anti-mouse Ig HRP (Rockland Immunochemicals, 18-8817-33); Anti-rabbit IgG HRP 353 (Rockland Immunochemicals, 18-8816-33); HRP-conjugated Mouse anti-Rabbit IgG 354 Light Chain (ABclonal, AS061); Prestained Protein Ladder 10-180 kDa (Thermo, 355 26616); Prestained Protein Ladder 25-400 kDa (Sevenbio, SW179). .. 356 4.2 Cells 357 CTLL-2 cells were purchased from the Cell Resource Center, Peking Union Medical 358 College (IBMS, CAMS/PUMC) and cultured in RPMI-1640 (Gibco) supplemented 359 with 10% fetal bovine serum (FBS) and 1× penicillin–streptomycin (Invitrogen), 10 360 mM HEPES, 1 mM Sodium pyruvate (Gibco), 2mM GlutaMAX (Gibco), and 100 361 U/ml IL-2.

    other:

    Article Title: Modulating Lysine Crotonylation in Ulcerative Colitis Maintains Mitochondrial Homeostasis
    Article Snippet: DSS (MP Biomedicals, Lot: S2839); anti‐crotonyllysine antibody (Jingjie PTM BioLab, PTM‐502; Lot: 1037267K306; 1:1000 dilution); anti‐succinyllysine antibody (PTM‐419; Lot: 1D05032317L804; 1:1000 dilution); anti‐malonyllysine antibody (PTM‐902; Lot: 23056103K312; 1: 1000 dilution); anti‐β‐hydroxybutyryllysine antibody (PTM‐1201RM; Lot: RL053142; 1:200 dilution); anti‐lactyllysine antibody (PTM‐1401RM; Lot: RL063009; 1:300 dilution); NaCr (Shanghai yuanye Bio‐Technology, Cas No.14379‐00‐1); LEGENDplex multi‐analyte flow assay kit (BioLegend, Cat No.741043); TUBULIN antibody (Proteintech, Cat No. 11224‐1‐AP; 1:5000 dilution); GAPDH antibody (Proteintech, Cat No. 60004‐1‐Ig; 1:5000 dilution); BAX antibody (Proteintech, Cat No. 60267‐1‐Ig; 1:5000 dilution); BCL2 antibody (Proteintech, Cat No. 68103‐1‐Ig; 1:2000 dilution); CS antibody (Abcam, ab129095; 1:1000 dilution); PINK1 antibody (Abcam, ab216144; 1:1000 dilution); PARKIN antibody (Abcam, ab77924; 1:2000 dilution); LC3B antibody (Abcam, ab192890; 1:2000 dilution); P62 antibody (Abcam, ab109012; 1:10000 dilution); NLRP3 antibody (Abcam, ab263899; 1:1000 dilution); primer synthesis (Beijing Tsingke Biotech Co., Ltd).

    Article Title: Modulating Lysine Crotonylation in Ulcerative Colitis Maintains Mitochondrial Homeostasis
    Article Snippet: DSS (MP Biomedicals, Lot: S2839); anti-crotonyllysine antibody (Jingjie PTM BioLab, PTM-502; Lot: 1037267K306; 1:1000 dilution); anti-succinyllysine antibody (PTM-419; Lot: 1D05032317L804; 1:1000 dilution); anti-malonyllysine antibody (PTM-902; Lot: 23056103K312; 1: 1000 dilution); antiβ-hydroxybutyryllysine antibody (PTM-1201RM; Lot: RL053142; 1:200 dilution); anti-lactyllysine antibody (PTM-1401RM; Lot: RL063009; 1:300 dilution); NaCr (Shanghai yuanye BioTechnology, Cas No.14379-00-1); LEGENDplex multi-analyte flow assay kit (BioLegend, Cat No.741043); TUBULIN antibody (Proteintech, Cat No. 11224-1-AP; 1:5000 dilution); GAPDH antibody (Proteintech, Cat No. 60004-1-Ig; 1:5000 dilution); BAX antibody (Proteintech, Cat No. 60267-1-Ig; 1:5000 dilution); BCL2 antibody (Proteintech, Cat No. 68103-1-Ig; 1:2000 dilution); CS 2 of 16 Exploration, 2025 27662098, 0, D ow nloaded from https://onlinelibrary.w iley.com /doi/10.1002/E X P.20240129 by N guyen T am - T aipei M edical U niversity(T m u) , W iley O nline L ibrary on [15/10/2025].



    Similar Products

    bcl2 rabbit ab  (Bioss)
    95
    Bioss bcl2 rabbit ab
    The mRNA expression of ITGAV, FAK, PLC, PKC, p65, ERK, JNK, p38, PI3K, Akt, Bax, <t>Bcl2</t> , and Caspase 3 in E.tenella host cells.
    Bcl2 Rabbit Ab, supplied by Bioss, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/bcl2+antibody/Bcl-2+Polyclonal+Antibody/pmc13125192-136-0-4
    Average 95 stars, based on 1 article reviews
    bcl2 rabbit ab - by Bioz Stars, 2026-09
    95/100 stars
    		  Buy from Supplier
    bcl2 monoclonal antibody  (Bioss)
    94
    Bioss bcl2 monoclonal antibody
    The mRNA expression of ITGAV, FAK, PLC, PKC, p65, ERK, JNK, p38, PI3K, Akt, Bax, <t>Bcl2</t> , and Caspase 3 in E.tenella host cells.
    Bcl2 Monoclonal Antibody, supplied by Bioss, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/bcl2+antibody/Bcl2+Monoclonal+Antibody/custom%40bsm-33047m%4010%2E3390%2Fvetsci13070628
    Average 94 stars, based on 1 article reviews
    bcl2 monoclonal antibody - by Bioz Stars, 2026-09
    94/100 stars
    		  Buy from Supplier
    bcl2 monoclonal antibody  (Wuhan Sanying Biotechnology)
    86
    Wuhan Sanying Biotechnology bcl2 monoclonal antibody
    The mRNA expression of ITGAV, FAK, PLC, PKC, p65, ERK, JNK, p38, PI3K, Akt, Bax, <t>Bcl2</t> , and Caspase 3 in E.tenella host cells.
    Bcl2 Monoclonal Antibody, supplied by Wuhan Sanying Biotechnology, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/bcl2+antibody/2+anti+bcl/pm42076148-59-16-0
    Average 86 stars, based on 1 article reviews
    bcl2 monoclonal antibody - by Bioz Stars, 2026-09
    86/100 stars
    		  Buy from Supplier
    bcl2  (Proteintech)
    96
    Proteintech bcl2
    NRP2 mediates the FAK signaling pathway to regulate the malignant progression of GBM cells. (A): NRP2 expression levels in patients from the GSE4290 and GSE68848 data sets. (B): The knockdown effect of sh-NRP2 in U251 and T98G cells was detected by qRT-PCR. (C): WB was used to detect the expressions of pY297-FAK and FAK. (D): The CCK-8 method was used to detect the cell viability of GBM cells in different treatment groups (sh-NC, sh-NRP2, sh-NRP2 + adhesamine). Adhesamine is a FAK activator. (E): The colony formation experiment was used to detect the number of colony formations of GBM cells in different treatment groups; (F): The scratch healing experiment was used to detect the migration ability of GBM cells in different treatment groups; (G): The Transwell experiment was used to detect the invasion ability of GBM cells in different treatment groups; (H): The Annexin V/PI double staining method was used to detect the apoptosis level of cells in different treatment groups. (I): Western blot was used to detect the protein expression of pro-apoptotic indicators clever-caspase3, clever-PARP, BAX and pro-apoptotic indicator <t>BCL2</t> in different treatment groups. * indicates P < 0.05, **** indicates P < 0.0001.
    Bcl2, supplied by Proteintech, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/bcl2+antibody/BCL2+Antibody/pmc13018971-13-0-2
    Average 96 stars, based on 1 article reviews
    bcl2 - by Bioz Stars, 2026-09
    96/100 stars
    		  Buy from Supplier
    bcl2  (Bioss)
    94
    Bioss bcl2
    NRP2 mediates the FAK signaling pathway to regulate the malignant progression of GBM cells. (A): NRP2 expression levels in patients from the GSE4290 and GSE68848 data sets. (B): The knockdown effect of sh-NRP2 in U251 and T98G cells was detected by qRT-PCR. (C): WB was used to detect the expressions of pY297-FAK and FAK. (D): The CCK-8 method was used to detect the cell viability of GBM cells in different treatment groups (sh-NC, sh-NRP2, sh-NRP2 + adhesamine). Adhesamine is a FAK activator. (E): The colony formation experiment was used to detect the number of colony formations of GBM cells in different treatment groups; (F): The scratch healing experiment was used to detect the migration ability of GBM cells in different treatment groups; (G): The Transwell experiment was used to detect the invasion ability of GBM cells in different treatment groups; (H): The Annexin V/PI double staining method was used to detect the apoptosis level of cells in different treatment groups. (I): Western blot was used to detect the protein expression of pro-apoptotic indicators clever-caspase3, clever-PARP, BAX and pro-apoptotic indicator <t>BCL2</t> in different treatment groups. * indicates P < 0.05, **** indicates P < 0.0001.
    Bcl2, supplied by Bioss, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/bcl2+antibody/BCL-2+(1A5)+Monoclonal+Antibody/10__1016_slash_j__anireprosci__2026__108229-102-20-25
    Average 94 stars, based on 1 article reviews
    bcl2 - by Bioz Stars, 2026-09
    94/100 stars
    		  Buy from Supplier
    anti bcl2 alexafluortm 647  (Novus Biologicals)
    94
    Novus Biologicals anti bcl2 alexafluortm 647
    NRP2 mediates the FAK signaling pathway to regulate the malignant progression of GBM cells. (A): NRP2 expression levels in patients from the GSE4290 and GSE68848 data sets. (B): The knockdown effect of sh-NRP2 in U251 and T98G cells was detected by qRT-PCR. (C): WB was used to detect the expressions of pY297-FAK and FAK. (D): The CCK-8 method was used to detect the cell viability of GBM cells in different treatment groups (sh-NC, sh-NRP2, sh-NRP2 + adhesamine). Adhesamine is a FAK activator. (E): The colony formation experiment was used to detect the number of colony formations of GBM cells in different treatment groups; (F): The scratch healing experiment was used to detect the migration ability of GBM cells in different treatment groups; (G): The Transwell experiment was used to detect the invasion ability of GBM cells in different treatment groups; (H): The Annexin V/PI double staining method was used to detect the apoptosis level of cells in different treatment groups. (I): Western blot was used to detect the protein expression of pro-apoptotic indicators clever-caspase3, clever-PARP, BAX and pro-apoptotic indicator <t>BCL2</t> in different treatment groups. * indicates P < 0.05, **** indicates P < 0.0001.
    Anti Bcl2 Alexafluortm 647, supplied by Novus Biologicals, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/bcl2+antibody/Bcl-2+Antibody+(124)+%5BAlexa+Fluor%C2%AE+647%5D/bio_rxiv__64898__2026__04__16__719078-77-6-21
    Average 94 stars, based on 1 article reviews
    anti bcl2 alexafluortm 647 - by Bioz Stars, 2026-09
    94/100 stars
    		  Buy from Supplier
    bcl 2  (Proteintech)
    96
    Proteintech bcl 2
    NRP2 mediates the FAK signaling pathway to regulate the malignant progression of GBM cells. (A): NRP2 expression levels in patients from the GSE4290 and GSE68848 data sets. (B): The knockdown effect of sh-NRP2 in U251 and T98G cells was detected by qRT-PCR. (C): WB was used to detect the expressions of pY297-FAK and FAK. (D): The CCK-8 method was used to detect the cell viability of GBM cells in different treatment groups (sh-NC, sh-NRP2, sh-NRP2 + adhesamine). Adhesamine is a FAK activator. (E): The colony formation experiment was used to detect the number of colony formations of GBM cells in different treatment groups; (F): The scratch healing experiment was used to detect the migration ability of GBM cells in different treatment groups; (G): The Transwell experiment was used to detect the invasion ability of GBM cells in different treatment groups; (H): The Annexin V/PI double staining method was used to detect the apoptosis level of cells in different treatment groups. (I): Western blot was used to detect the protein expression of pro-apoptotic indicators clever-caspase3, clever-PARP, BAX and pro-apoptotic indicator <t>BCL2</t> in different treatment groups. * indicates P < 0.05, **** indicates P < 0.0001.
    Bcl 2, supplied by Proteintech, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/bcl2+antibody/BCL2+Antibody/pmc12995874-11-0-2
    Average 96 stars, based on 1 article reviews
    bcl 2 - by Bioz Stars, 2026-09
    96/100 stars
    		  Buy from Supplier
    anti bax  (Proteintech)
    96
    Proteintech anti bax
    NRP2 mediates the FAK signaling pathway to regulate the malignant progression of GBM cells. (A): NRP2 expression levels in patients from the GSE4290 and GSE68848 data sets. (B): The knockdown effect of sh-NRP2 in U251 and T98G cells was detected by qRT-PCR. (C): WB was used to detect the expressions of pY297-FAK and FAK. (D): The CCK-8 method was used to detect the cell viability of GBM cells in different treatment groups (sh-NC, sh-NRP2, sh-NRP2 + adhesamine). Adhesamine is a FAK activator. (E): The colony formation experiment was used to detect the number of colony formations of GBM cells in different treatment groups; (F): The scratch healing experiment was used to detect the migration ability of GBM cells in different treatment groups; (G): The Transwell experiment was used to detect the invasion ability of GBM cells in different treatment groups; (H): The Annexin V/PI double staining method was used to detect the apoptosis level of cells in different treatment groups. (I): Western blot was used to detect the protein expression of pro-apoptotic indicators clever-caspase3, clever-PARP, BAX and pro-apoptotic indicator <t>BCL2</t> in different treatment groups. * indicates P < 0.05, **** indicates P < 0.0001.
    Anti Bax, supplied by Proteintech, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/bcl2+antibody/BCL2+Antibody/pm41933050-88-6-7
    Average 96 stars, based on 1 article reviews
    anti bax - by Bioz Stars, 2026-09
    96/100 stars
    		  Buy from Supplier
    anti cyclin b1  (Proteintech)
    96
    Proteintech anti cyclin b1
    NRP2 mediates the FAK signaling pathway to regulate the malignant progression of GBM cells. (A): NRP2 expression levels in patients from the GSE4290 and GSE68848 data sets. (B): The knockdown effect of sh-NRP2 in U251 and T98G cells was detected by qRT-PCR. (C): WB was used to detect the expressions of pY297-FAK and FAK. (D): The CCK-8 method was used to detect the cell viability of GBM cells in different treatment groups (sh-NC, sh-NRP2, sh-NRP2 + adhesamine). Adhesamine is a FAK activator. (E): The colony formation experiment was used to detect the number of colony formations of GBM cells in different treatment groups; (F): The scratch healing experiment was used to detect the migration ability of GBM cells in different treatment groups; (G): The Transwell experiment was used to detect the invasion ability of GBM cells in different treatment groups; (H): The Annexin V/PI double staining method was used to detect the apoptosis level of cells in different treatment groups. (I): Western blot was used to detect the protein expression of pro-apoptotic indicators clever-caspase3, clever-PARP, BAX and pro-apoptotic indicator <t>BCL2</t> in different treatment groups. * indicates P < 0.05, **** indicates P < 0.0001.
    Anti Cyclin B1, supplied by Proteintech, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/bcl2+antibody/BCL2+Antibody/pm41933050-88-12-14
    Average 96 stars, based on 1 article reviews
    anti cyclin b1 - by Bioz Stars, 2026-09
    96/100 stars
    		  Buy from Supplier
    anti bcl2  (Proteintech)
    96
    Proteintech anti bcl2
    NRP2 mediates the FAK signaling pathway to regulate the malignant progression of GBM cells. (A): NRP2 expression levels in patients from the GSE4290 and GSE68848 data sets. (B): The knockdown effect of sh-NRP2 in U251 and T98G cells was detected by qRT-PCR. (C): WB was used to detect the expressions of pY297-FAK and FAK. (D): The CCK-8 method was used to detect the cell viability of GBM cells in different treatment groups (sh-NC, sh-NRP2, sh-NRP2 + adhesamine). Adhesamine is a FAK activator. (E): The colony formation experiment was used to detect the number of colony formations of GBM cells in different treatment groups; (F): The scratch healing experiment was used to detect the migration ability of GBM cells in different treatment groups; (G): The Transwell experiment was used to detect the invasion ability of GBM cells in different treatment groups; (H): The Annexin V/PI double staining method was used to detect the apoptosis level of cells in different treatment groups. (I): Western blot was used to detect the protein expression of pro-apoptotic indicators clever-caspase3, clever-PARP, BAX and pro-apoptotic indicator <t>BCL2</t> in different treatment groups. * indicates P < 0.05, **** indicates P < 0.0001.
    Anti Bcl2, supplied by Proteintech, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/bcl2+antibody/BCL2+Antibody/pm41933050-88-9-10
    Average 96 stars, based on 1 article reviews
    anti bcl2 - by Bioz Stars, 2026-09
    96/100 stars
    		  Buy from Supplier

    Image Search Results


    The mRNA expression of ITGAV, FAK, PLC, PKC, p65, ERK, JNK, p38, PI3K, Akt, Bax, Bcl2 , and Caspase 3 in E.tenella host cells.

    Journal: Poultry Science

    Article Title: Pathogenic mechanism of Eimeria tenella Et MIC2 promotes Eimeria tenella invasion and inhibits host cell apoptosis through binding to the ITGAV receptor

    doi: 10.1016/j.psj.2026.106922

    Figure Lengend Snippet: The mRNA expression of ITGAV, FAK, PLC, PKC, p65, ERK, JNK, p38, PI3K, Akt, Bax, Bcl2 , and Caspase 3 in E.tenella host cells.

    Article Snippet: Bcl2 Rabbit Ab , Bioss , bs-0032R , 1: 1500.

    Techniques: Expressing

    The protein activity changes of ITGAV, FAK, PLC, PKC, p65, ERK, JNK, p38, PI3K, Akt, Bax, Bcl2, and Caspase 3 in E.tenella host cells.

    Journal: Poultry Science

    Article Title: Pathogenic mechanism of Eimeria tenella Et MIC2 promotes Eimeria tenella invasion and inhibits host cell apoptosis through binding to the ITGAV receptor

    doi: 10.1016/j.psj.2026.106922

    Figure Lengend Snippet: The protein activity changes of ITGAV, FAK, PLC, PKC, p65, ERK, JNK, p38, PI3K, Akt, Bax, Bcl2, and Caspase 3 in E.tenella host cells.

    Article Snippet: Bcl2 Rabbit Ab , Bioss , bs-0032R , 1: 1500.

    Techniques: Activity Assay

    NRP2 mediates the FAK signaling pathway to regulate the malignant progression of GBM cells. (A): NRP2 expression levels in patients from the GSE4290 and GSE68848 data sets. (B): The knockdown effect of sh-NRP2 in U251 and T98G cells was detected by qRT-PCR. (C): WB was used to detect the expressions of pY297-FAK and FAK. (D): The CCK-8 method was used to detect the cell viability of GBM cells in different treatment groups (sh-NC, sh-NRP2, sh-NRP2 + adhesamine). Adhesamine is a FAK activator. (E): The colony formation experiment was used to detect the number of colony formations of GBM cells in different treatment groups; (F): The scratch healing experiment was used to detect the migration ability of GBM cells in different treatment groups; (G): The Transwell experiment was used to detect the invasion ability of GBM cells in different treatment groups; (H): The Annexin V/PI double staining method was used to detect the apoptosis level of cells in different treatment groups. (I): Western blot was used to detect the protein expression of pro-apoptotic indicators clever-caspase3, clever-PARP, BAX and pro-apoptotic indicator BCL2 in different treatment groups. * indicates P < 0.05, **** indicates P < 0.0001.

    Journal: Translational Oncology

    Article Title: The brain imaging feature-related gene NRP2 drives the malignant progression of glioblastoma through the FAK pathway: a Mendelian randomization study

    doi: 10.1016/j.tranon.2026.102732

    Figure Lengend Snippet: NRP2 mediates the FAK signaling pathway to regulate the malignant progression of GBM cells. (A): NRP2 expression levels in patients from the GSE4290 and GSE68848 data sets. (B): The knockdown effect of sh-NRP2 in U251 and T98G cells was detected by qRT-PCR. (C): WB was used to detect the expressions of pY297-FAK and FAK. (D): The CCK-8 method was used to detect the cell viability of GBM cells in different treatment groups (sh-NC, sh-NRP2, sh-NRP2 + adhesamine). Adhesamine is a FAK activator. (E): The colony formation experiment was used to detect the number of colony formations of GBM cells in different treatment groups; (F): The scratch healing experiment was used to detect the migration ability of GBM cells in different treatment groups; (G): The Transwell experiment was used to detect the invasion ability of GBM cells in different treatment groups; (H): The Annexin V/PI double staining method was used to detect the apoptosis level of cells in different treatment groups. (I): Western blot was used to detect the protein expression of pro-apoptotic indicators clever-caspase3, clever-PARP, BAX and pro-apoptotic indicator BCL2 in different treatment groups. * indicates P < 0.05, **** indicates P < 0.0001.

    Article Snippet: BCL2 , Proteintech , China , 12,789-1-AP , Rabbit , 1:9000.

    Techniques: Expressing, Knockdown, Quantitative RT-PCR, CCK-8 Assay, Migration, Double Staining, Western Blot

    NRP2 promotes the malignant progression of GBM by activating FAK. U251 and T98G cell groups: sh-NC, sh-NRP2, sh-NRP2 + oe-FAK. (A): qRT-PCR was used to detect the mRNA level of FAK; (B): WB was used to detect the protein expression of pY397-FAK and FAK; (C): CCK-8 was used to detect cell viability; (D): Scratch test was used to detect the migration ability of cells; (E): Transwell test was used to detect the invasion ability of cells; (F): WB was used to detect the protein expression of apoptotic proteins clever-caspase3, clever-PARP, BAX and anti-apoptotic protein BCL2. * indicates P < 0.05.

    Journal: Translational Oncology

    Article Title: The brain imaging feature-related gene NRP2 drives the malignant progression of glioblastoma through the FAK pathway: a Mendelian randomization study

    doi: 10.1016/j.tranon.2026.102732

    Figure Lengend Snippet: NRP2 promotes the malignant progression of GBM by activating FAK. U251 and T98G cell groups: sh-NC, sh-NRP2, sh-NRP2 + oe-FAK. (A): qRT-PCR was used to detect the mRNA level of FAK; (B): WB was used to detect the protein expression of pY397-FAK and FAK; (C): CCK-8 was used to detect cell viability; (D): Scratch test was used to detect the migration ability of cells; (E): Transwell test was used to detect the invasion ability of cells; (F): WB was used to detect the protein expression of apoptotic proteins clever-caspase3, clever-PARP, BAX and anti-apoptotic protein BCL2. * indicates P < 0.05.

    Article Snippet: BCL2 , Proteintech , China , 12,789-1-AP , Rabbit , 1:9000.

    Techniques: Quantitative RT-PCR, Expressing, CCK-8 Assay, Migration

    The nude mouse experiment demonstrates that NRP2 mediates the Focal-adhesion pathway to regulate the formation of GBM tumors. (A): Nude mice were subcutaneously injected with sh-NRP2 and sh-NC stably transfected T98G cells. Comparison of tumor size in sh-NRP2 nude mice treated with FAK activator adhesamine. (B): Tumor weights of different treatment groups of nude mice. (C): Tumor volumes of different treatment groups of nude mice. (D): IHC detection of the expression of Ki67, BCL2 and BAX in tumor tissues; (E): WB detection of the expression of pY297-FAK and FAK in tumor tissues.

    Journal: Translational Oncology

    Article Title: The brain imaging feature-related gene NRP2 drives the malignant progression of glioblastoma through the FAK pathway: a Mendelian randomization study

    doi: 10.1016/j.tranon.2026.102732

    Figure Lengend Snippet: The nude mouse experiment demonstrates that NRP2 mediates the Focal-adhesion pathway to regulate the formation of GBM tumors. (A): Nude mice were subcutaneously injected with sh-NRP2 and sh-NC stably transfected T98G cells. Comparison of tumor size in sh-NRP2 nude mice treated with FAK activator adhesamine. (B): Tumor weights of different treatment groups of nude mice. (C): Tumor volumes of different treatment groups of nude mice. (D): IHC detection of the expression of Ki67, BCL2 and BAX in tumor tissues; (E): WB detection of the expression of pY297-FAK and FAK in tumor tissues.

    Article Snippet: BCL2 , Proteintech , China , 12,789-1-AP , Rabbit , 1:9000.

    Techniques: Injection, Stable Transfection, Transfection, Comparison, Expressing